What single biological function has been essential to every living organism’s growth, health and advancement – and is more important than any other?
It’s called cell signalling; the ability for one cell in the body to ‘talk’ to another. Now here’s another question for you. What biological process does one in every three pharmaceutical drugs attempt to assist? Cell Signalling. Now there’s a link between today and our lifeforms all the way back to ‘slime’. University of British Columbia researchers have identified a common ancestral gene. This gene’s function – cell signalling – enabled the evolution of advanced life over a billion years ago. Found in all complex organisms, including plants and animals, it ‘encodes’ for a large group of enzymes known as protein kinases that enable cells to rapidly transfer information from one cell to another. “If the duplications and subsequent mutations of this gene during evolution didn’t happen, then life would be completely different today,” said Steven Pelech, a professor in Division of Neurology in the UBC Faculty of Medicine. “The most advanced life on our planet would probably still be bacterial slime.” Plants, animals, mushrooms and more all exist because they are made up of eukaryotic cells that are larger and far more complex than bacteria. Within these eukaryotic cells are hundreds of organelles that perform billions of diverse functions to keep them living, just as different organs do for the human body. The new research, published this week in the Journal of Biological Chemistry, identified the gene that gave rise to protein kinases. On a cellular scale, these highly interactive signaling proteins play a role similar to the neurons in the brain by transferring information throughout the cell by a process known as protein phosphorylation. This ability to transmit signals from one part of the cell to another not only enabled cells to become more complex internally, but also allowed cells to come together to form systems, paving the way for the evolution of intelligent life.
Research into these enzymes is obviously very important to medicine. There are more than 400 human diseases like cancer and diabetes linked to problems with cell signaling.
Disease occurs when a cell gets misinformed or confused. Today about one-third of all pharmaceutical drug development is targeted at protein kinases. For more than 30 years, researchers have known that most protein kinases came from a common ancestor because their genes are so similar. “From sequencing the genomes of humans, we knew that about 500 genes for different protein kinases all had similar blueprints,” said Pelech. “Our new research revealed that the gene probably originated from bacteria for facilitating the synthesis of proteins and then mutated to acquire completely new functions.” Cell signalling has another ally which is most unlike any pharmaceutical drug. Molecular hydrogen is the subject of 700 scientific studies, over a 150+ range of disease conditions, and as well as been identified as a potential selective antioxidant, anti-inflammatory and anti-allergenic, it has also been studies for its ability to assist cell signalling. Why should we care? We have our cupboard full of pills and potions. Why should we try molecular hydrogen? The secret lies in its nature. H2 – molecular hydrogen is the smallest molecule in the universe, made up of two of the smallest atoms in the universe. This gives it unique properties that place it in a class of its own. Firstly, its size means the once in the body it has the ability to pass through nay part of the body, including bone, muscle, even into the mitochondria within a single cell. Secondly, it is a simple molecule. What it does – it’s shouldn’t do. Pharma giants are shaking their heads in disbelief at the results users are claiming – results normally reserved for expensive and complex formulated drugs. In truth, at this stage of research, no-one knows why it has so many therapeutic effects, but the results are certainly obvious in the studies. Want to learn more? Check this slide show prepared by Erica Whisson, Alkaway’s inhouse naturopath.
And.. if you’d like to try molecular hydrogen for yourself, here’s two ways. The UltraStream I LOVE H2
Scientists have discovered a new way information may be traveling throughout the brain. The team has identified slow-moving brainwaves it says could be carried only by the brain’s gentle electrical field, a mechanism previously thought to be incapable of spreading neural signals altogether. (I’ll tell you why I think this is important at the end of this article.) Dominique Durand, professor of biomedical engineering at Case Western Reserve University says “Researchers have thought that the brain’s endogenous electrical fields are too weak to propagate wave transmission, But it appears the brain may be using the fields to communicate without synaptic transmissions, gap junctions or diffusion.” What led Durand and her team of researchers to this conclusion was the recording of neural spikes traveling too slowly to be carried by conventional means, indicating something else was at play. They claim that the only possible explanation for the passage of information in this way was the presence of a weak electrical field. The team tested its theory both by way of computer modeling and observing activity in the hippocampus of a mouse brain, the central region associated with memory and spatial navigation. While the electrical field was weak, with an amplitude of around 2.6 mV/mm, the team found that beginning with one cell or a group of cells, the field was able to stimulate neighboring neurons which in turn stimulated their neighboring neurons. This resulted in a spread of signals throughout the brain at a rate of around 10 cm per second. By blocking the electrical field and increasing the distance between the cells in the computer model, the team found they could slow down the speed of the wave. This furthered their belief that the mild electrical field is in fact behind the propagation of these type of brain signals. “Others have been working on this phenomena for decades, but no one has ever made these connections,” says Steven J. Schiff, director of the Center for Neural Engineering at Penn State University, who was not involved in the study. “The implications are that such directed fields can be used to modulate both pathological activities, such as seizures, and to interact with cognitive rhythms that help regulate a variety of processes in the brain.” The research team says that the newly unearthed mechanism could be behind the spread of neural signals such as sleep and theta waves (those associated with memory formation during sleep), along with epileptic seizure waves, all of which travel at around 1 m per second. They are now exploring what part, if any, they play in epilepsy and regular brain function. If a role is established, they will seek to uncover what information the fields are carrying and where exactly they begin. The research was published in The Journal of Neuroscience. Source: Case Western Reserve University/EurekAlert Ian: I have become very interested in cell signalling since I realised that perhaps the most valuable benefit of molecular hydrogen is in its ability to support cell signalling. For those of us not yet aware, cell signalling is what happens millions of times a minute in the supercomputer we call the body. It’s the process where one element of the body wants to ‘tell’ another part of the body something, e.g. ‘Move my left leg’. Contemplating this will soon lead you to a realisation of the massive number of messages our body processes along with the infinite complexity of organising this process of cell signalling. I recently turned 69 and I drink my Ultrastream hydrogen infused water every day, but to ‘up’ the H2 concentration, I first pour it from my UltraStream into a 350ml bottle, to the top, ad 2 x I LOVE H2 tablets that dissolve and release more hydrogen, so I have what some may call a ‘megadose’ of infused H2. I know from study and experience that the higher the concentration of H2 in my water, the more effect it has on my body. How do I feel? Sharp as a tack. I work hard here at the AlkaWay office every day, and I do attribute that (at my age) to the effect molecular hydrogen has on my internal super computer. If you’d like to know more about molecular hydrogen, go here, or download our 17 page report on the science of H2 here.
Alkaway resident Naturopath Erica has just completed a presentation of her summation of the scientific studies on cell signalling.
Cell signalling is something few people understand, but let’s face it- that’s a pretty weak reason to ignore it, especially if it holds powerful health benefits. The analogy that seems to make most sense to me is of a new oil that we could put into our little Nissans that would instantly give them the performance of a Mercedes Benz. Nothing changes in our body: what we have is simply supported to operate to its true full capability. Cell signalling is the body’s communication system at a molecular level, its internal ‘Skype’ that allows every part of our body to message another part and ask it to perform the action it needs to be at optimum health-supporting performance. I know it’s difficult to understand it but I can assure you that it’s – in my opinion – maybe the biggest natural health breakthrough of the century. How do you get the report? see below. How do you access molecular hydrogen? Click here